Targeting BRIX1 via Engineered Exosomes Induces Nucleolar Stress to Suppress Cancer Progression

Targeting BRIX1 via Engineered Exosomes Induces Nucleolar Stress to Suppress Cancer Progression

Abstract Elevated ribosome biogenesis correlates with the rapid growth and progression of cancer. Targeted blockade of ribosome biogenesis induces nucleolar stress, which preferentially leads to the elimination of malignant cells. In this study, it is reported that the nucleolar protein BRIX1 is a c...

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Main Authors: Yu Gan, Qian Hao, Tao Han, Jing Tong, Qingya Yan, Hongguang Zhong, Bo Gao, Yanan Li, Zhisheng Xuan, Pengfei Li, Litong Yao, Yingying Xu, Yi‐Zhou Jiang, Zhi‐Ming Shao, Jun Deng, Jiaxiang Chen, Xiang Zhou
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
BRIX1
engineered exosomes
nucleolar stress
p53
ribosome biogenesis
targeted therapy
Online Access:https://doi.org/10.1002/advs.202407370
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https://doi.org/10.1002/advs.202407370

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