Seasonal Chemical Variability and Antimicrobial, Anti-Proliferative Potential of Essential Oils from <i>Baccharis uncinella</i>, <i>B. retusa</i>, and <i>B. calvescens</i> (Asteraceae)

Essential oils (EOs) of three native species <i>Baccharis uncinella</i>, <i>B. retusa</i> and <i>B. calvescens</i>, obtained through hydrodistillation, were analyzed by GC-MS and GC-FID for seasonality, and the antimicrobial and anti-proliferative activities were...

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Main Authors: Tânia F. Dlugoviet, Aurea P. Ferriani, Ana Paula P. Klein Hendges, Rebeca G. Camargo, Marta C. T. Duarte, Renata M. T. Duarte, Ana Lúcia Tasca Gois Ruiz, Noemi Nagata, Francisco A. Marques, Beatriz H. L. N. Sales Maia
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Language:English
Published: MDPI AG 2025-04-01
Series:Plants
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Online Access:https://www.mdpi.com/2223-7747/14/9/1311
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author Tânia F. Dlugoviet
Aurea P. Ferriani
Ana Paula P. Klein Hendges
Rebeca G. Camargo
Marta C. T. Duarte
Renata M. T. Duarte
Ana Lúcia Tasca Gois Ruiz
Noemi Nagata
Francisco A. Marques
Beatriz H. L. N. Sales Maia
author_facet Tânia F. Dlugoviet
Aurea P. Ferriani
Ana Paula P. Klein Hendges
Rebeca G. Camargo
Marta C. T. Duarte
Renata M. T. Duarte
Ana Lúcia Tasca Gois Ruiz
Noemi Nagata
Francisco A. Marques
Beatriz H. L. N. Sales Maia
author_sort Tânia F. Dlugoviet
collection DOAJ
description Essential oils (EOs) of three native species <i>Baccharis uncinella</i>, <i>B. retusa</i> and <i>B. calvescens</i>, obtained through hydrodistillation, were analyzed by GC-MS and GC-FID for seasonality, and the antimicrobial and anti-proliferative activities were evaluated. EO of <i>B. calvescens</i> and <i>B. uncinella</i> consisted mainly of oxygenated sesquiterpenes, while in the EO of <i>B. retusa</i>, monoterpene hydrocarbons were predominant. The highest antimicrobial activity was observed for spring <i>B. uncinella</i> EO against <i>S. aureus</i>, <i>C. albicans</i> and summer <i>B. uncinella</i> EO against <i>C. albicans</i> and <i>B. subtilis</i>. Essential oils of <i>B. calvescens</i> showed more effective anti-proliferative activity than <i>B. retusa</i> EO and <i>B. uncinella</i> EO. This is the first study of the EO of <i>B. retusa</i>, and it was demonstrated that the majority composition was different in all seasons of the year, justifying the importance of the seasonal study. Furthermore, the summer and spring EO showed potent cytostatic effects against the K562 and OVCAR-03 cell lines, respectively. For each species, PCA differentiated the EO chemical composition seasonally. PCA of all samples distinguished the three species. This study underscores the importance of assessing seasonal variation in the chemical composition and biological activities of essential oils, highlighting the potential of compounds spathulenol, caryophyllene oxide, limonene and α-pinene for achieving the desired product properties.
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spelling doaj-art-f99e80f36b8043d487d989ea1d59c78f2025-08-20T02:31:08ZengMDPI AGPlants2223-77472025-04-01149131110.3390/plants14091311Seasonal Chemical Variability and Antimicrobial, Anti-Proliferative Potential of Essential Oils from <i>Baccharis uncinella</i>, <i>B. retusa</i>, and <i>B. calvescens</i> (Asteraceae)Tânia F. Dlugoviet0Aurea P. Ferriani1Ana Paula P. Klein Hendges2Rebeca G. Camargo3Marta C. T. Duarte4Renata M. T. Duarte5Ana Lúcia Tasca Gois Ruiz6Noemi Nagata7Francisco A. Marques8Beatriz H. L. N. Sales Maia9Departamento de Química, Universidade Federal do Paraná, Curitiba 81531-980, PR, BrazilDepartamento de Química, Universidade Federal do Paraná, Curitiba 81531-980, PR, BrazilCentral de Análises, Universidade Tecnológica Federal do Paraná, Pato Branco 85503-390, PR, BrazilDepartamento de Química, Universidade Federal do Paraná, Curitiba 81531-980, PR, BrazilDivisão de Microbiologia, CPQBA, Universidade Estadual de Campinas, Campinas 13148-218, SP, BrazilDivisão de Microbiologia, CPQBA, Universidade Estadual de Campinas, Campinas 13148-218, SP, BrazilFCF, Universidade Estadual de Campinas, Campinas 13083-871, SP, BrazilDepartamento de Química, Universidade Federal do Paraná, Curitiba 81531-980, PR, BrazilDepartamento de Química, Universidade Federal do Paraná, Curitiba 81531-980, PR, BrazilDepartamento de Química, Universidade Federal do Paraná, Curitiba 81531-980, PR, BrazilEssential oils (EOs) of three native species <i>Baccharis uncinella</i>, <i>B. retusa</i> and <i>B. calvescens</i>, obtained through hydrodistillation, were analyzed by GC-MS and GC-FID for seasonality, and the antimicrobial and anti-proliferative activities were evaluated. EO of <i>B. calvescens</i> and <i>B. uncinella</i> consisted mainly of oxygenated sesquiterpenes, while in the EO of <i>B. retusa</i>, monoterpene hydrocarbons were predominant. The highest antimicrobial activity was observed for spring <i>B. uncinella</i> EO against <i>S. aureus</i>, <i>C. albicans</i> and summer <i>B. uncinella</i> EO against <i>C. albicans</i> and <i>B. subtilis</i>. Essential oils of <i>B. calvescens</i> showed more effective anti-proliferative activity than <i>B. retusa</i> EO and <i>B. uncinella</i> EO. This is the first study of the EO of <i>B. retusa</i>, and it was demonstrated that the majority composition was different in all seasons of the year, justifying the importance of the seasonal study. Furthermore, the summer and spring EO showed potent cytostatic effects against the K562 and OVCAR-03 cell lines, respectively. For each species, PCA differentiated the EO chemical composition seasonally. PCA of all samples distinguished the three species. This study underscores the importance of assessing seasonal variation in the chemical composition and biological activities of essential oils, highlighting the potential of compounds spathulenol, caryophyllene oxide, limonene and α-pinene for achieving the desired product properties.https://www.mdpi.com/2223-7747/14/9/1311<i>Baccharis</i>seasonal variationanti-proliferative activityantimicrobial activity
spellingShingle Tânia F. Dlugoviet
Aurea P. Ferriani
Ana Paula P. Klein Hendges
Rebeca G. Camargo
Marta C. T. Duarte
Renata M. T. Duarte
Ana Lúcia Tasca Gois Ruiz
Noemi Nagata
Francisco A. Marques
Beatriz H. L. N. Sales Maia
Seasonal Chemical Variability and Antimicrobial, Anti-Proliferative Potential of Essential Oils from <i>Baccharis uncinella</i>, <i>B. retusa</i>, and <i>B. calvescens</i> (Asteraceae)
Plants
<i>Baccharis</i>
seasonal variation
anti-proliferative activity
antimicrobial activity
title Seasonal Chemical Variability and Antimicrobial, Anti-Proliferative Potential of Essential Oils from <i>Baccharis uncinella</i>, <i>B. retusa</i>, and <i>B. calvescens</i> (Asteraceae)
title_full Seasonal Chemical Variability and Antimicrobial, Anti-Proliferative Potential of Essential Oils from <i>Baccharis uncinella</i>, <i>B. retusa</i>, and <i>B. calvescens</i> (Asteraceae)
title_fullStr Seasonal Chemical Variability and Antimicrobial, Anti-Proliferative Potential of Essential Oils from <i>Baccharis uncinella</i>, <i>B. retusa</i>, and <i>B. calvescens</i> (Asteraceae)
title_full_unstemmed Seasonal Chemical Variability and Antimicrobial, Anti-Proliferative Potential of Essential Oils from <i>Baccharis uncinella</i>, <i>B. retusa</i>, and <i>B. calvescens</i> (Asteraceae)
title_short Seasonal Chemical Variability and Antimicrobial, Anti-Proliferative Potential of Essential Oils from <i>Baccharis uncinella</i>, <i>B. retusa</i>, and <i>B. calvescens</i> (Asteraceae)
title_sort seasonal chemical variability and antimicrobial anti proliferative potential of essential oils from i baccharis uncinella i i b retusa i and i b calvescens i asteraceae
topic <i>Baccharis</i>
seasonal variation
anti-proliferative activity
antimicrobial activity
url https://www.mdpi.com/2223-7747/14/9/1311
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