Targeting protein-protein interactions in drug discovery: Modulators approved or in clinical trials for cancer treatment

Targeting protein-protein interactions in drug discovery: Modulators approved or in clinical trials for cancer treatment

Protein-protein interactions (PPIs) form complex cellular networks fundamental to many key biological processes, including signal transduction, cell proliferation and DNA repair. In consequence, their perturbation is often associated with many human diseases. Targeting PPIs offers a promising approa...

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Bibliographic Details
Main Authors: Cristina Camps-Fajol, Debora Cavero, Jordi Minguillón, Jordi Surrallés
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Pharmacological Research
Subjects:
Protein-protein interaction
PPI
Modulators
Approved
Clinical trials
Cancer treatment
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661824004894
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http://www.sciencedirect.com/science/article/pii/S1043661824004894

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