PMMA nanoplastics induce gastric epithelial cellular senescence and cGAS-STING-mediated inflammation via ROS overproduction and NHEJ suppression

PMMA nanoplastics induce gastric epithelial cellular senescence and cGAS-STING-mediated inflammation via ROS overproduction and NHEJ suppression

The increasing environmental presence of nanoplastics (NPs) has raised concerns about their potential impact on biological systems. We investigated the repercussions of polymethyl methacrylate (PMMA) NPs exposure on normal gastric epithelial cells and revealed a pronounced increase in senescence-ass...

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Bibliographic Details
Main Authors: Xiao Li, Yixing Huang, Dan Zu, Haidong Liu, Hanyi He, Qimei Bao, Yanhua He, Chen Liang, Guoyan Luo, Yaoshu Teng, Yin Shi, Zu Ye, Xiangdong Cheng
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Ecotoxicology and Environmental Safety
Subjects:
PMMA nanoplastics
Cellular senescence
ROS
NHEJ
Genomic instability
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651324013605
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