Increased Plasma β‐Secretase 1 Activity Correlates With Neurodegeneration in Cerebral Small Vessel Disease

Increased Plasma β‐Secretase 1 Activity Correlates With Neurodegeneration in Cerebral Small Vessel Disease

Background β‐secretase 1 (BACE1) plays a key role in amyloidogenic pathway and is considered a new mechanism for cerebral small vessel disease (CSVD). We explore the potential role of plasma BACE1 in CSVD and the pathological process it may be involved in. Methods and Results We enrolled 163 partici...

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Bibliographic Details
Main Authors: Ya Su, Qiong Wang, Feng Gao, Jiajie Xu, Jiayu Fu, Yunqing Ying, Yiwei Xia, Xiaoxiao Wang, Qiang Dong, Yong Shen, Xin Cheng
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cerebral amyloid angiopathy
cerebral small vessel disease
hypertensive arteriopathy
neurodegeneration
β‐secretase 1
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.036204
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https://www.ahajournals.org/doi/10.1161/JAHA.124.036204

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