Assessing the Role of Clinicopathologic Factors in Outcome Prediction in Subjects Having Oropharyngeal Carcinoma Associated with Human Papillomavirus and Managed with Surgery
Background: Human papillomavirus (HPV) has been linked as a potential risk factor for increasing incidence of oropharyngeal carcinoma. Aim: The present study aimed to evaluate the role of clinicopathologic factors in outcome prediction in subjects having oropharyngeal carcinoma associated with HPV a...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_1436_24 |
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| Summary: | Background:
Human papillomavirus (HPV) has been linked as a potential risk factor for increasing incidence of oropharyngeal carcinoma.
Aim:
The present study aimed to evaluate the role of clinicopathologic factors in outcome prediction in subjects having oropharyngeal carcinoma associated with HPV and managed with surgery.
Methods:
The present retrospective study assessed data from 54 subjects that were diagnosed with stage III or IV HPV-associated oropharyngeal carcinoma were managed with surgery with or without adjuvant therapy.
Results:
The mean follow-up duration in the study subjects was 2.7 years. The recurrence-free survival and overall survival rates [age, number of lymph nodes involved, stage of tumor, and Charleston comorbidity index] in the study subjects were 83% and 71% and 62% and 79%, respectively. The recurrence rate in the study was found to be 21%.
Conclusion:
The conclusion drawn from the present study is that some associated potential risk factors can have lesser relevance in HPV-associated oropharyngeal carcinoma. |
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| ISSN: | 0976-4879 0975-7406 |