Suppression of microtubule acetylation mediates the anti-leukemic effect of CDK9 inhibition

Suppression of microtubule acetylation mediates the anti-leukemic effect of CDK9 inhibition

Abstract Cyclin-dependent kinase 9 (CDK9) is a crucial component of transcription and potential target for anti-cancer therapies, particularly for hematological malignancies. However, the precise mechanisms underlying the therapeutic effects of CDK9 inhibitors remain not fully understood. Here, we f...

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Main Authors: Xi Xie, Baoyuan Zhang, Donghe Li, Jiaming Gao, Jiaoyang Li, Chenxuan Liu, Yuqing Dan, Pengfei Xu, Lei Yan, Xu Huang, Rui Zhang, Yunying Yao, Wei Huang, Jiawei Nie, Xinru Wang, Bo Jiao, Ruibao Ren, Ping Liu
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cancer Cell International
Subjects:
CDK9
Microtubule acetylation
ATAT1
Online Access:https://doi.org/10.1186/s12935-024-03588-8
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https://doi.org/10.1186/s12935-024-03588-8

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