Validated HPLC Methodology for Pregabalin Quantification in Human Urine Using 1-Fluoro-2,4-dinitrobenzene Derivatization

Validated HPLC Methodology for Pregabalin Quantification in Human Urine Using 1-Fluoro-2,4-dinitrobenzene Derivatization

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Pregabalin (PGB) is a synthetic drug used for the treatment of central nervous system disorders and neuropathic pain. PGB is metabolized to N-Methyl pregabalin while the rest is excreted virtually unchanged in the urine. Numerous analytical techniques for measuring pregabalin have been documented....

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Bibliographic Details
Main Authors: Mohamedsaid mostafa Said Mostafa, Hosam Abdel Fattah Mohamed Elshebiny, Olfat Elsayed Mostafa, Shimaa Talaat Elsayed, Mohamed Abdelizm Abdelaziz
Format: Article
Language:English
Published: Universidade Federal do Rio Grande do Sul 2024-12-01
Series:Drug Analytical Research
Subjects:
Pregabalin
1-Fluoro-2,4-dinitrobenzene
derivatization
validation
HPLC analysis
Online Access:https://seer.ufrgs.br/index.php/dar/article/view/143059
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