Theabrownin combined with zearalenone suppresses colitis-associated colorectal cancer by inhibiting PI3K/AKT pathway and enhancing microbial propionate production

Theabrownin combined with zearalenone suppresses colitis-associated colorectal cancer by inhibiting PI3K/AKT pathway and enhancing microbial propionate production

Abstract Colorectal cancer (CRC) is both a leading cause of cancer-related mortality and one of the most frequently diagnosed cancers. Previous studies have shown that zearalenone and theabrownin each exert anti-CRC effects. Here, we aimed to evaluate the anti-tumor properties of theabrownin and zea...

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Main Authors: Hoi Kit Matthew Leung, Emily Kwun Kwan Lo, Congjia Chen, Fangfei Zhang, Felicianna, Marsena Jasiel Ismaiah, Hani El-Nezami
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
TZ
Colorectal cancer
Gut microbiota
Gut mycobiota
Short-chain fatty acids
Online Access:https://doi.org/10.1038/s41598-025-11820-2
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https://doi.org/10.1038/s41598-025-11820-2

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