Adjunctive ketamine vs. buprenorphine in co-occurring major depressive disorder and opioid use disorder: a randomized, double-blind clinical trial assessing anxiety symptom severity and craving intensity

Adjunctive ketamine vs. buprenorphine in co-occurring major depressive disorder and opioid use disorder: a randomized, double-blind clinical trial assessing anxiety symptom severity and craving intensity

Abstract Background The concomitant presence of major depressive disorder (MDD) and opioid use disorder (OUD) poses a formidable clinical challenge, warranting effective interventions that address both psychiatric and addictive components. Aims This study sought to compare the efficacy of adjunctive...

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Bibliographic Details
Main Authors: Arash Mansoori, Amir Bazrafshan, Jamshid Ahmadi, Seyed Hamdollah Mosavat
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Trials
Subjects:
Major depressive disorder
Opioid use disorder
Ketamine
Buprenorphine
Anxiety
Craving
Online Access:https://doi.org/10.1186/s13063-025-08836-4
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https://doi.org/10.1186/s13063-025-08836-4

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