Novel targeted therapies in chronic myeloid leukemia

Novel targeted therapies in chronic myeloid leukemia

Chronic myeloid leukemia (CML) is the chronic proliferation of myeloid-lineage cells in hematopoietic stem cells driven by the BCR-ABL1 fusion oncoprotein. The development of tyrosine kinase inhibitors (TKIs) has revolutionized CML treatment; however, resistance and intolerance to these drugs remain...

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Bibliographic Details
Main Authors: Muhammad Sameer Ashaq, Qian Zhou, Zhuoran Li, Baobing Zhao
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Pharmaceutical Science Advances
Subjects:
Chronic myeloid leukemia
Stem cells
BCR-ABL1
Tyrosine kinase inhibitors
Targeted therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2773216924000187
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