Stimulation of corticospinal neurons by optogenetic cAMP inductions promotes motor recovery after spinal cord injury in female rats via raphespinal tract modulation

Stimulation of corticospinal neurons by optogenetic cAMP inductions promotes motor recovery after spinal cord injury in female rats via raphespinal tract modulation

Abstract After spinal cord injury (SCI), cyclic adenosine monophosphate (cAMP) levels drop in the spinal cord, cortex and brainstem, unlike in regenerating peripheral neurons. To address SCI recovery, we expressed photoactivatable adenylate cyclase (bPAC) in corticospinal neurons of female rats with...

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Main Authors: Beatriz Martínez-Rojas, Samuel Martín-Pérez, Esther Giraldo, Eric Lopez-Mocholi, Ana Alastrue, Yuniesky Andrade-Talavera, Jose Prius-Mengual, Guillem Paniagua, Maria Pedraza, Sonia Hingorani, Benjamin R. Rost, Dietmar Schmitz, Marta Llansola, Vicente Felipo, Antonio Rodríguez-Moreno, Victoria Moreno-Manzano
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61018-3
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