Hepatocyte reporter cells and integrated metabolomic and transcriptomic analyses reveal insights into hepatocyte changes in offspring of pregnancies with obesity

Hepatocyte reporter cells and integrated metabolomic and transcriptomic analyses reveal insights into hepatocyte changes in offspring of pregnancies with obesity

Abstract Infants born to mothers with obesity have increased risk for later development of metabolic dysfunction-associated steatotic liver disease (MASLD); however early hepatic changes that occur in these infants remain unclear. We integrated metabolomic analysis of umbilical cord plasma and trans...

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Bibliographic Details
Main Authors: Svetlana Y. Kozlovich, Amy Y. Pan, Jennifer J. McIntosh, Anna Palatnik, Shuang Jia, Martin J. Hessner, T. Hang Nghiem-Rao
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Maternal obesity
Cord plasma
Metabolomics
Transcriptomics
Online Access:https://doi.org/10.1038/s41598-025-10808-2
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