Comparison of the diagnostic capabilities of tNGS and mNGS for pathogens causing lower respiratory tract infections: a prospective observational study

Comparison of the diagnostic capabilities of tNGS and mNGS for pathogens causing lower respiratory tract infections: a prospective observational study

AimsPathogens in lower respiratory tract infections(LRTI) are complex. Conventional microbiological testings(CMTs) are time-consuming and inaccurate. mNGS is widely used to overcome these issues. tNGS, as an emerging NGS technology, has uncertain diagnostic efficacy.Materials and methods136 suspecte...

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Main Authors: Yuchen Ding, Chuwei Jing, Jiachen Wei, Danni Wang, Wen Li, Mingyue Wang, Ji Zhou, Qian Qian, Wenkui Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
lower respiratory tract infection
NGS - next generation sequencing
mNGS (metagenomic next-generation sequencing)
targeted next generation sequencing (tNGS)
diagnosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1578939/full
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https://www.frontiersin.org/articles/10.3389/fcimb.2025.1578939/full

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