Thyroid hormone receptor beta (THRβ1) is the major regulator of T3 action in human iPSC-derived hepatocytes

Thyroid hormone receptor beta (THRβ1) is the major regulator of T3 action in human iPSC-derived hepatocytes

Objective: Thyroid hormone (TH) action is mediated by thyroid hormone receptor (THR) isoforms. While THRβ1 is likely the main isoform expressed in liver, its role in human hepatocytes is not fully understood. Methods: To elucidate the role of THRβ1 action in human hepatocytes we used CRISPR/Cas9 edi...

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Bibliographic Details
Main Authors: Lorraine Soares De Oliveira, Joseph E. Kaserman, Anne H. Van Der Spek, Nora J. Lee, Hendrik J. Undeutsch, Rhiannon B. Werder, Andrew A. Wilson, Anthony N. Hollenberg
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Molecular Metabolism
Subjects:
iPSC-derived hepatocytes
THRB
Thyroid hormone
Liver metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877824001881
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