Bivalent single-domain antibodies show potent mpox virus neutralization through M1R antigen

Bivalent single-domain antibodies show potent mpox virus neutralization through M1R antigen

Abstract Despite the recent mpox outbreak raising global concerns, no fully validated antiviral treatment exists, highlighting the urgent need for effective therapeutics. Here, by taking advantage of the preparation technology for single-domain (VHH) antibodies, we generated VHHs targeting the six m...

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Main Authors: Daisuke Akazawa, Masayuki Shimojima, Eun-Sil Park, Akiko Okutani, Milagros Virhuez-Mendoza, Yusuke Inoue, Takayuki Hishiki, Ken Maeda, Hideki Ebihara, Yoshimasa Takahashi, Koichi Watashi
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08494-x
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