APOE4 and age affect the brain entorhinal cortex structure and blood arachidonic acid and docosahexaenoic acid levels after mild TBI

APOE4 and age affect the brain entorhinal cortex structure and blood arachidonic acid and docosahexaenoic acid levels after mild TBI

Abstract A reduction in the thickness and volume of the brain entorhinal cortex (EC), together with changes in blood arachidonic acid (AA) and docosahexaenoic acid (DHA), are associated with Alzheimer’s disease (AD) among apolipoprotein E ε4 carriers. Magnetic Resonance Imaging (n = 631) and plasma...

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Main Authors: Gregory Aldrich, James E. Evans, Roderick Davis, Lucia Jurin, Sarah Oberlin, Daniel Niedospial, Aurore Nkiliza, Michael Mullan, Kimbra Kenney, J. Kent Werner, Katie Edwards, Jessica M. Gill, Hannah M. Lindsey, Emily L. Dennis, William C. Walker, Elisabeth Wilde, Fiona Crawford, Laila Abdullah
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Traumatic brain injury
Blast injury
Repetitive mild traumatic brain injury
Apolipoprotein E
Entorhinal cortex
Arachidonic acid
Online Access:https://doi.org/10.1038/s41598-024-80153-3
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https://doi.org/10.1038/s41598-024-80153-3

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