Extracellular vesicles from ovarian cancer cells induce senescent lipid-laden macrophages to facilitate omental metastasis

Extracellular vesicles from ovarian cancer cells induce senescent lipid-laden macrophages to facilitate omental metastasis

Abstract Background Ovarian cancer exhibits striking metastatic tropism for the omentum, where lipid-laden macrophages are key mediators that fuel disease progression. However, the mechanisms governing their formation and pro-metastatic functions remain poorly understood. As extracellular vesicles (...

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Main Authors: Guoqing Li, Xiaoling Zhou, Wenhan Li, Qiulei Wu, Tong Liu, Lin Huang, Xiaoli Liu, Jing Zhao, Xiaohan Xu, Linjuan Xu, Zehua Wang, Lanqing Gong, Liqiong Cai, Jing Cai
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Nanobiotechnology
Online Access:https://doi.org/10.1186/s12951-025-03612-7
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https://doi.org/10.1186/s12951-025-03612-7

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