Cowpea bean β-vignin-derived AQQSY peptide exerts an anticancer effect by inducing cell cycle arrest in the G0/G1 phase and modulating apoptotic signals

Cowpea bean β-vignin-derived AQQSY peptide exerts an anticancer effect by inducing cell cycle arrest in the G0/G1 phase and modulating apoptotic signals

The anticancer effect of digested β-vignin and pure peptides from cowpea beans was investigated in cultivated human colon cancer cells. The effect of AQQSY on the cell cycle was similar to that of palbociclib, suggesting that AQQSY may function as a CDK-6-targeting agent. AQQSY peptide reduced the p...

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Bibliographic Details
Main Authors: Biane Oliveira Philadelpho, Johnnie Elton Machado dos Santos, Emily Elaine Davis, Mariana Barros de Cerqueira e Silva, Eduardo Maffud Cilli, Ederlan de Souza Ferreira, Elvira González de Mejia
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Journal of Functional Foods
Subjects:
Vigna unguiculata
Bioactive peptides
Docking
Cell cycle arrest
Bax/Bcl-2. HCT-116 cells
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464624005000
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