An automated blood test for glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) to predict the absence of intracranial lesions on head CT in adult patients with mild traumatic brain injury: BRAINI, a multicentre observational study in EuropeResearch in context

An automated blood test for glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) to predict the absence of intracranial lesions on head CT in adult patients with mild traumatic brain injury: BRAINI, a multicentre observational study in EuropeResearch in context

Summary: Background: Following mild traumatic brain injury (mTBI), elevated concentrations of brain-specific blood proteins glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1) may be indicative of intracranial lesions normally detected by head CT scans. We sought t...

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Main Authors: Alfonso Lagares, Javier de la Cruz, Hugo Terrisse, Odile Mejan, Vladislav Pavlov, Celine Vermorel, Jean-François Payen, Maxime Maignan, Damien Viglino, Laurent Jacquin, Marion Douplat, Said Laribi, Philippe Pes, Patrick Ray, Jérémy Guenezan, Mustapha Sebbane, Frédéric Belen, Guillaume Durand, Cordelia Abric, Cédric Gil-Jardiné, Pudaru Mihai, Julián Morales, Ana Castuera, Ana María Castano-Leon, Juan Delgado, Jose F. Alen
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:EBioMedicine
Subjects:
Mild traumatic brain injury
Biomarkers
Diagnosis
Clinical laboratory techniques
CT scan
Prognosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396424005139
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