Application of a new composite genetic marker semen-specific methylation-microhaplotype in the analysis of semen–vaginal fluid mixtures

Application of a new composite genetic marker semen-specific methylation-microhaplotype in the analysis of semen–vaginal fluid mixtures

DNA mixtures containing semen and vaginal fluid are common biological samples in forensic analysis. However, the analysis of semen–vaginal fluid mixtures remains challenging. In this study, to solve these problems, it is proposed to combine semen-specific CpG sites and closely related microhaplotype...

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Bibliographic Details
Main Authors: Dan Wen, Hao Xing, Xuan Tang, Yue Wang, Bowei Jiang, Jienan Li, Ying Liu, Lagabaiyila Zha
Format: Article
Language:English
Published: The Royal Society 2025-01-01
Series:Royal Society Open Science
Subjects:
forensic genetics
DNA methylation
microhaplotype
semen–vaginal fluid mixtures
K-nearest neighbour algorithm
massively parallel sequencing
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsos.241565
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https://royalsocietypublishing.org/doi/10.1098/rsos.241565

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