Molecular Decoration and Unconventional Double Bond Migration in Irumamycin Biosynthesis

Molecular Decoration and Unconventional Double Bond Migration in Irumamycin Biosynthesis

Irumamycin (Iru) is a complex polyketide with pronounced antifungal activity produced by a type I polyketide (PKS) synthase. Iru features a unique hemiketal ring and an epoxide group, making its biosynthesis and the structural diversity of related compounds particularly intriguing. In this study, we...

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Main Authors: Vera A. Alferova, Anna A. Baranova, Olga A. Belozerova, Evgeny L. Gulyak, Andrey A. Mikhaylov, Yaroslav V. Solovev, Mikhail Y. Zhitlov, Arseniy A. Sinichich, Anton P. Tyurin, Ekaterina A. Trusova, Alexey V. Beletsky, Andrey V. Mardanov, Nikolai V. Ravin, Olda A. Lapchinskaya, Vladimir A. Korshun, Alexander G. Gabibov, Stanislav S. Terekhov
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Antibiotics
Subjects:
type I polyketide synthase
olefin shift
biosynthetic gene cluster
epoxidation
antibiotic
<i>Streptomyces</i> sp.
Online Access:https://www.mdpi.com/2079-6382/13/12/1167
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