Transcriptomic analysis reinforces the implication of spatacsin in neuroinflammation and neurodevelopment

Transcriptomic analysis reinforces the implication of spatacsin in neuroinflammation and neurodevelopment

Abstract Hereditary spastic paraplegia (HSP) encompasses a group of rare genetic diseases primarily affecting motor neurons. Among these, spastic paraplegia type 11 (SPG11) represents a complex form of HSP caused by deleterious variants in the SPG11 gene, which encodes the spatacsin protein. Previou...

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Bibliographic Details
Main Authors: Liriopé Toupenet Marchesi, Daniel Stockholm, Typhaine Esteves, Marion Leblanc, Nicolas Auger, Julien Branchu, Khalid Hamid El Hachimi, Giovanni Stevanin
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Spastic paraplegia
Transcriptomic analysis
Mouse model
SPG11
DEG
GSEA
Online Access:https://doi.org/10.1038/s41598-025-86337-9
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