Immunoinformatic design of a multivalent vaccine against Brucella abortus and its evaluation in a murine model using a DNA prime-protein boost strategy

Immunoinformatic design of a multivalent vaccine against Brucella abortus and its evaluation in a murine model using a DNA prime-protein boost strategy

IntroductionThe development of effective vaccines against Brucella abortus is critical due to its significant impact on human and animal health. The objective of this study was to design and evaluate in silico and in vivo a multivalent vaccine based on the immunogenic potential of three selected ope...

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Bibliographic Details
Main Authors: Raúl E. Molina, Alberto Osorio, Manuel Flores-Concha, Leonardo A. Gómez, Ilse Alvarado, Italo Ferrari, Angel Oñate
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
prime-boost strategy
multivalent vaccines
immunoinformatic
molecular dynamics
immunogenicity
protection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1456078/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1456078/full

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