High‐Throughput Single‐Nucleus RNA Profiling of Minimal Puncture FFPE Samples Reveals Spatiotemporal Heterogeneity of Cancer

High‐Throughput Single‐Nucleus RNA Profiling of Minimal Puncture FFPE Samples Reveals Spatiotemporal Heterogeneity of Cancer

Abstract Puncture biopsy, especially those preserved by formalin fixed paraffin embedding (FFPE) samples, play an important role in various research purposes. Diverse single‐nucleus RNA sequencing (snRNA‐seq) techniques have been developed for FFPE samples, however, how to perform high‐throughput sn...

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Bibliographic Details
Main Authors: Weiqin Jiang, Xiang Zhang, Ziye Xu, Qing Cheng, Xiaohan Li, Yuyi Zhu, Fangru Lu, Ling Dong, Linghui Zeng, Weixiang Zhong, Yongcheng Wang, Longjiang Fan, Hongyu Chen
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Advanced Science
Subjects:
FFPE sample
noncoding RNA
puncture biopsy
pseudoprogression
spatiotemporal heterogeneity
Online Access:https://doi.org/10.1002/advs.202410713
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