The histone H3 lysine 36 demethylase KDM2A/FBXL11 controls Polycomb-mediated gene repression and germ cell development in male mice

The histone H3 lysine 36 demethylase KDM2A/FBXL11 controls Polycomb-mediated gene repression and germ cell development in male mice

Abstract KDM2A/FBXL11 is a Jumonji-domain containing lysine demethylase catalyzing the removal of mono- and di-methyl modifications of histone H3 lysine 36 (H3K36me1/2). While Kdm2a is required for mouse embryogenesis, its role in adult physiology has been largely unexplored. Using conditional delet...

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Main Authors: Michael T. Bocker, Grigorios Fanourgakis, Kristie Wetzel, Pavel A. Komarov, Hélène Royo, Alexia Rohmer, Sunwoo Chun, Ching-Yeu Liang, Hubertus Kohler, Taiping Chen, Xiaohong Mao, Mark A. Labow, Reginald A. Valdez, Michael B. Stadler, Dirk G. de Rooij, Paola Capodieci, John Tallarico, Antoine H. F. M. Peters, Thomas B. Nicholson
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61733-x
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https://doi.org/10.1038/s41467-025-61733-x

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