fmo-4 promotes longevity and stress resistance via ER to mitochondria calcium regulation in C. elegans

fmo-4 promotes longevity and stress resistance via ER to mitochondria calcium regulation in C. elegans

Flavin-containing monooxygenases (FMOs) are a conserved family of xenobiotic enzymes upregulated in multiple longevity interventions, including nematode and mouse models. Previous work supports that C. elegans fmo-2 promotes longevity, stress resistance, and healthspan by rewiring endogenous metabol...

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Bibliographic Details
Main Authors: Angela M Tuckowski, Safa Beydoun, Elizabeth S Kitto, Ajay Bhat, Marshall B Howington, Aditya Sridhar, Mira Bhandari, Kelly Chambers, Scott F Leiser
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-02-01
Series:eLife
Subjects:
aging
flavin-containing monooxygenase
stress resistance
calcium
ER
mitochondria
Online Access:https://elifesciences.org/articles/99971
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https://elifesciences.org/articles/99971

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