Chest CT Airway and Vascular Measurements in Females with COPD or Long-COVID
Chest CT provides a way to quantify pulmonary airway and vascular tree measurements. In patients with COPD, CT airway measurement differences in females are concomitant with worse quality-of-life and other outcomes. CT total airway count (TAC), airway lumen area (LA), and wall thickness (WT) also di...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | COPD |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15412555.2024.2394129 |
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| author | Harkiran K. Kooner Paulina V. Wyszkiewicz Alexander M. Matheson Marrissa J. McIntosh Mohamed Abdelrazek Inderdeep Dhaliwal J. Michael Nicholson Miranda Kirby Sarah Svenningsen Grace Parraga |
| author_facet | Harkiran K. Kooner Paulina V. Wyszkiewicz Alexander M. Matheson Marrissa J. McIntosh Mohamed Abdelrazek Inderdeep Dhaliwal J. Michael Nicholson Miranda Kirby Sarah Svenningsen Grace Parraga |
| author_sort | Harkiran K. Kooner |
| collection | DOAJ |
| description | Chest CT provides a way to quantify pulmonary airway and vascular tree measurements. In patients with COPD, CT airway measurement differences in females are concomitant with worse quality-of-life and other outcomes. CT total airway count (TAC), airway lumen area (LA), and wall thickness (WT) also differ in females with long-COVID. Our objective was to evaluate CT airway and pulmonary vascular and quality-of-life measurements in females with COPD as compared to ex-smokers and patients with long-COVID. Chest CT was acquired 3-months post-COVID-19 infection in females with long-COVID for comparison with the same inspiratory CT in female ex-smokers and COPD patients. TAC, LA, WT, and pulmonary vascular measurements were quantified. Linear regression models were adjusted for confounders including age, height, body-mass-index, lung volume, pack-years and asthma diagnosis. Twenty-one females (53 ± 14 years) with long-COVID, 17 female ex-smokers (69 ± 9 years) and 13 female COPD (67 ± 6 years) patients were evaluated. In the absence of differences in quality-of-life scores, females with long-COVID reported significantly different LA (p = 0.006) compared to ex-smokers but not COPD (p = 0.7); WT% was also different compared to COPD (p = 0.009) but not ex-smokers (p = 0.5). In addition, there was significantly greater pulmonary small vessel volume (BV5) in long-COVID as compared to female ex-smokers (p = 0.045) and COPD (p = 0.003) patients and different large (BV10) vessel volume as compared to COPD (p = 0.03). In females with long-COVID and highly abnormal quality-of-life scores, there was CT evidence of airway remodelling, similar to ex-smokers and patients with COPD, but there was no evidence of pulmonary vascular remodelling.Clinical Trial Registration: www.clinicaltrials.gov NCT05014516 and NCT02279329 |
| format | Article |
| id | doaj-art-f6800977c9644b15989bffbb6fdc877e |
| institution | Kabale University |
| issn | 1541-2555 1541-2563 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | COPD |
| spelling | doaj-art-f6800977c9644b15989bffbb6fdc877e2024-12-26T08:50:44ZengTaylor & Francis GroupCOPD1541-25551541-25632024-12-0121110.1080/15412555.2024.2394129Chest CT Airway and Vascular Measurements in Females with COPD or Long-COVIDHarkiran K. Kooner0Paulina V. Wyszkiewicz1Alexander M. Matheson2Marrissa J. McIntosh3Mohamed Abdelrazek4Inderdeep Dhaliwal5J. Michael Nicholson6Miranda Kirby7Sarah Svenningsen8Grace Parraga9Robarts Research Institute, Western University, London, CanadaRobarts Research Institute, Western University, London, CanadaRobarts Research Institute, Western University, London, CanadaRobarts Research Institute, Western University, London, CanadaDepartment of Medical Imaging, Western University, London, CanadaDivision of Respirology, Department of Medicine, Western University, London, CanadaDivision of Respirology, Department of Medicine, Western University, London, CanadaDepartment of Physics, Toronto Metropolitan University, Toronto, CanadaDivision of Respirology, Department of Medicine, McMaster University and Firestone Institute for Respiratory Health, St Joseph’s Health Care, Hamilton, CanadaRobarts Research Institute, Western University, London, CanadaChest CT provides a way to quantify pulmonary airway and vascular tree measurements. In patients with COPD, CT airway measurement differences in females are concomitant with worse quality-of-life and other outcomes. CT total airway count (TAC), airway lumen area (LA), and wall thickness (WT) also differ in females with long-COVID. Our objective was to evaluate CT airway and pulmonary vascular and quality-of-life measurements in females with COPD as compared to ex-smokers and patients with long-COVID. Chest CT was acquired 3-months post-COVID-19 infection in females with long-COVID for comparison with the same inspiratory CT in female ex-smokers and COPD patients. TAC, LA, WT, and pulmonary vascular measurements were quantified. Linear regression models were adjusted for confounders including age, height, body-mass-index, lung volume, pack-years and asthma diagnosis. Twenty-one females (53 ± 14 years) with long-COVID, 17 female ex-smokers (69 ± 9 years) and 13 female COPD (67 ± 6 years) patients were evaluated. In the absence of differences in quality-of-life scores, females with long-COVID reported significantly different LA (p = 0.006) compared to ex-smokers but not COPD (p = 0.7); WT% was also different compared to COPD (p = 0.009) but not ex-smokers (p = 0.5). In addition, there was significantly greater pulmonary small vessel volume (BV5) in long-COVID as compared to female ex-smokers (p = 0.045) and COPD (p = 0.003) patients and different large (BV10) vessel volume as compared to COPD (p = 0.03). In females with long-COVID and highly abnormal quality-of-life scores, there was CT evidence of airway remodelling, similar to ex-smokers and patients with COPD, but there was no evidence of pulmonary vascular remodelling.Clinical Trial Registration: www.clinicaltrials.gov NCT05014516 and NCT02279329https://www.tandfonline.com/doi/10.1080/15412555.2024.2394129CTCOVID-19long-COVIDcoronavirus diseaseCOPDpulmonary airways |
| spellingShingle | Harkiran K. Kooner Paulina V. Wyszkiewicz Alexander M. Matheson Marrissa J. McIntosh Mohamed Abdelrazek Inderdeep Dhaliwal J. Michael Nicholson Miranda Kirby Sarah Svenningsen Grace Parraga Chest CT Airway and Vascular Measurements in Females with COPD or Long-COVID COPD CT COVID-19 long-COVID coronavirus disease COPD pulmonary airways |
| title | Chest CT Airway and Vascular Measurements in Females with COPD or Long-COVID |
| title_full | Chest CT Airway and Vascular Measurements in Females with COPD or Long-COVID |
| title_fullStr | Chest CT Airway and Vascular Measurements in Females with COPD or Long-COVID |
| title_full_unstemmed | Chest CT Airway and Vascular Measurements in Females with COPD or Long-COVID |
| title_short | Chest CT Airway and Vascular Measurements in Females with COPD or Long-COVID |
| title_sort | chest ct airway and vascular measurements in females with copd or long covid |
| topic | CT COVID-19 long-COVID coronavirus disease COPD pulmonary airways |
| url | https://www.tandfonline.com/doi/10.1080/15412555.2024.2394129 |
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