Pharmacological enhancement of slow-wave activity at an early disease stage improves cognition and reduces amyloid pathology in a mouse model of Alzheimer’s disease

Pharmacological enhancement of slow-wave activity at an early disease stage improves cognition and reduces amyloid pathology in a mouse model of Alzheimer’s disease

IntroductionImproving sleep in murine Alzheimer’s disease (AD) is associated with reduced brain amyloidosis. However, the window of opportunity for successful sleep-targeted interventions, regarding the reduction in pathological hallmarks and related cognitive performance, remains poorly characteriz...

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Bibliographic Details
Main Authors: Sedef Kollarik, Dorita Bimbiryte, Aakriti Sethi, Inês Dias, Carlos G. Moreira, Daniela Noain
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
sleep
memory
mouse model
amyloidosis
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2024.1519225/full
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