Reduced circulating regulatory T cells in primary Sjögren’s syndrome: the contribution of enhanced apoptosis and impaired survival

Reduced circulating regulatory T cells in primary Sjögren’s syndrome: the contribution of enhanced apoptosis and impaired survival

BackgroundRegulatory T cells (Tregs) are found to be critical for maintaining immune tolerance to self-antigens; however, their status in primary Sjögren’s syndrome (pSS) remains unclear. We investigated alterations in the abundance of peripheral Tregs in a large pSS cohort and their implications fo...

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Bibliographic Details
Main Authors: Yanlin Wang, Yuhan Jia, Hui Guo, Min Feng, Yan Qin, Zhaojun Liang, Xiangcong Zhao, Chong Gao, Jing Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
primary Sjögren’s syndrome
regulatory T cells
apoptosis
Caspase3
effector T cells (Teffs)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1603305/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1603305/full

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