Shikonin induces the apoptosis and pyroptosis of EGFR-T790M-mutant drug-resistant non-small cell lung cancer cells via the degradation of cyclooxygenase-2

Shikonin induces the apoptosis and pyroptosis of EGFR-T790M-mutant drug-resistant non-small cell lung cancer cells via the degradation of cyclooxygenase-2

Abstract Background The T790M mutation in the epidermal growth factor receptor (EGFR) gene is the primary cause of resistance to EGFR-tyrosine kinase inhibitor (TKI) therapy in non-small cell lung cancer (NSCLC) patients. Previous research demonstrated that certain traditional Chinese medicine (TCM)...

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Main Authors: Shaoyi Cao, Huaqiu Li, Xiaoyan Ye, Xinxing Xing, Yonghuan Xie, Xiangfeng Zeng, Hongjiao Liu, Xing Zhong, Xinyi Yang, Wenxiu Xing, Cairong Zhu, Xiaoping Wu
Format: Article
Language:English
Published: BMC 2024-12-01
Series:European Journal of Medical Research
Subjects:
Apoptosis
Cyclooxygenase-2 (COX-2)
Epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) resistance
Pyroptosis
Shikonin
Online Access:https://doi.org/10.1186/s40001-024-02187-7
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https://doi.org/10.1186/s40001-024-02187-7

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