Crisdesalazine alleviates inflammation in an experimental autoimmune encephalomyelitis multiple sclerosis mouse model by regulating the immune system
Abstract Microglia/macrophages participate in the development of and recovery from experimental autoimmune encephalomyelitis (EAE), and the macrophage M1 (pro-inflammatory)/M2 (anti-inflammatory) phase transition is involved in EAE disease progression. We evaluated the efficacy of crisdesalazine (a...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | BMC Neuroscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12868-024-00920-w |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841559852396052480 |
|---|---|
| author | Su-Min Park Yong-Hun Oh Ga-Hyun Lim Ju-Hyun An Jin-Hwan Lee Byoung-Joo Gwag So-Jung Won Kyoung-Won Seo Hwa-Young Youn |
| author_facet | Su-Min Park Yong-Hun Oh Ga-Hyun Lim Ju-Hyun An Jin-Hwan Lee Byoung-Joo Gwag So-Jung Won Kyoung-Won Seo Hwa-Young Youn |
| author_sort | Su-Min Park |
| collection | DOAJ |
| description | Abstract Microglia/macrophages participate in the development of and recovery from experimental autoimmune encephalomyelitis (EAE), and the macrophage M1 (pro-inflammatory)/M2 (anti-inflammatory) phase transition is involved in EAE disease progression. We evaluated the efficacy of crisdesalazine (a novel microsomal prostaglandin E2 synthase-1 inhibitor) in an EAE model, including its immune-regulating potency in lipopolysaccharide-stimulated macrophages, and its neuroprotective effects in a macrophage-neuronal co-culture system. Crisdesalazine significantly alleviated clinical symptoms, inhibited inflammatory cell infiltration and demyelination in the spinal cord, and altered the phase of microglial/macrophage and regulatory T cells. Crisdesalazine promoted the M1 to M2 phase transition in macrophages (immunomodulation) and reduced neuronal necrosis (neuroprotection) in vitro. This is the first study to directly demonstrate the therapeutic effects of a microsomal prostaglandin E2 synthase-1 inhibitor in an EAE model and its ability to alter macrophage polarization, suggesting that it may be a new therapeutic option for the treatment of patients affected by multiple sclerosis and other autoimmune diseases. |
| format | Article |
| id | doaj-art-f5ee6b71d3ea4e3ebe8c608bd053575d |
| institution | Kabale University |
| issn | 1471-2202 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neuroscience |
| spelling | doaj-art-f5ee6b71d3ea4e3ebe8c608bd053575d2025-01-05T12:09:38ZengBMCBMC Neuroscience1471-22022025-01-0126111310.1186/s12868-024-00920-wCrisdesalazine alleviates inflammation in an experimental autoimmune encephalomyelitis multiple sclerosis mouse model by regulating the immune systemSu-Min Park0Yong-Hun Oh1Ga-Hyun Lim2Ju-Hyun An3Jin-Hwan LeeByoung-Joo Gwag4So-Jung Won5Kyoung-Won Seo6Hwa-Young Youn7Laboratory of Veterinary Internal Medicine, Department of Clinical Veterinary Science, College of Veterinary Medicine, Seoul National UniversityLaboratory of Veterinary Internal Medicine, Department of Clinical Veterinary Science, College of Veterinary Medicine, Seoul National UniversityLaboratory of Veterinary Internal Medicine, Department of Clinical Veterinary Science, College of Veterinary Medicine, Seoul National UniversityDepartment of Veterinary Emergency and Critical Care Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National UniversityGNT Pharma Co. Ltd.GNT Pharma Co. Ltd.Laboratory of Veterinary Internal Medicine, Department of Clinical Veterinary Science, College of Veterinary Medicine, Seoul National UniversityLaboratory of Veterinary Internal Medicine, Department of Clinical Veterinary Science, College of Veterinary Medicine, Seoul National UniversityAbstract Microglia/macrophages participate in the development of and recovery from experimental autoimmune encephalomyelitis (EAE), and the macrophage M1 (pro-inflammatory)/M2 (anti-inflammatory) phase transition is involved in EAE disease progression. We evaluated the efficacy of crisdesalazine (a novel microsomal prostaglandin E2 synthase-1 inhibitor) in an EAE model, including its immune-regulating potency in lipopolysaccharide-stimulated macrophages, and its neuroprotective effects in a macrophage-neuronal co-culture system. Crisdesalazine significantly alleviated clinical symptoms, inhibited inflammatory cell infiltration and demyelination in the spinal cord, and altered the phase of microglial/macrophage and regulatory T cells. Crisdesalazine promoted the M1 to M2 phase transition in macrophages (immunomodulation) and reduced neuronal necrosis (neuroprotection) in vitro. This is the first study to directly demonstrate the therapeutic effects of a microsomal prostaglandin E2 synthase-1 inhibitor in an EAE model and its ability to alter macrophage polarization, suggesting that it may be a new therapeutic option for the treatment of patients affected by multiple sclerosis and other autoimmune diseases.https://doi.org/10.1186/s12868-024-00920-wAnti-inflammationCrisdesalazineExperimental autoimmune encephalomyelitisMicrosomal prostaglandin E2 synthase-1Macrophage |
| spellingShingle | Su-Min Park Yong-Hun Oh Ga-Hyun Lim Ju-Hyun An Jin-Hwan Lee Byoung-Joo Gwag So-Jung Won Kyoung-Won Seo Hwa-Young Youn Crisdesalazine alleviates inflammation in an experimental autoimmune encephalomyelitis multiple sclerosis mouse model by regulating the immune system BMC Neuroscience Anti-inflammation Crisdesalazine Experimental autoimmune encephalomyelitis Microsomal prostaglandin E2 synthase-1 Macrophage |
| title | Crisdesalazine alleviates inflammation in an experimental autoimmune encephalomyelitis multiple sclerosis mouse model by regulating the immune system |
| title_full | Crisdesalazine alleviates inflammation in an experimental autoimmune encephalomyelitis multiple sclerosis mouse model by regulating the immune system |
| title_fullStr | Crisdesalazine alleviates inflammation in an experimental autoimmune encephalomyelitis multiple sclerosis mouse model by regulating the immune system |
| title_full_unstemmed | Crisdesalazine alleviates inflammation in an experimental autoimmune encephalomyelitis multiple sclerosis mouse model by regulating the immune system |
| title_short | Crisdesalazine alleviates inflammation in an experimental autoimmune encephalomyelitis multiple sclerosis mouse model by regulating the immune system |
| title_sort | crisdesalazine alleviates inflammation in an experimental autoimmune encephalomyelitis multiple sclerosis mouse model by regulating the immune system |
| topic | Anti-inflammation Crisdesalazine Experimental autoimmune encephalomyelitis Microsomal prostaglandin E2 synthase-1 Macrophage |
| url | https://doi.org/10.1186/s12868-024-00920-w |
| work_keys_str_mv | AT suminpark crisdesalazinealleviatesinflammationinanexperimentalautoimmuneencephalomyelitismultiplesclerosismousemodelbyregulatingtheimmunesystem AT yonghunoh crisdesalazinealleviatesinflammationinanexperimentalautoimmuneencephalomyelitismultiplesclerosismousemodelbyregulatingtheimmunesystem AT gahyunlim crisdesalazinealleviatesinflammationinanexperimentalautoimmuneencephalomyelitismultiplesclerosismousemodelbyregulatingtheimmunesystem AT juhyunan crisdesalazinealleviatesinflammationinanexperimentalautoimmuneencephalomyelitismultiplesclerosismousemodelbyregulatingtheimmunesystem AT jinhwanlee crisdesalazinealleviatesinflammationinanexperimentalautoimmuneencephalomyelitismultiplesclerosismousemodelbyregulatingtheimmunesystem AT byoungjoogwag crisdesalazinealleviatesinflammationinanexperimentalautoimmuneencephalomyelitismultiplesclerosismousemodelbyregulatingtheimmunesystem AT sojungwon crisdesalazinealleviatesinflammationinanexperimentalautoimmuneencephalomyelitismultiplesclerosismousemodelbyregulatingtheimmunesystem AT kyoungwonseo crisdesalazinealleviatesinflammationinanexperimentalautoimmuneencephalomyelitismultiplesclerosismousemodelbyregulatingtheimmunesystem AT hwayoungyoun crisdesalazinealleviatesinflammationinanexperimentalautoimmuneencephalomyelitismultiplesclerosismousemodelbyregulatingtheimmunesystem |