Improved Biological Impacts of Anti-EGFR Monoclonal Antibody in KRAS-Mutant Colorectal Cancer Cells by Silica-Coated Magnetic Nanoparticle Conjugation

Improved Biological Impacts of Anti-EGFR Monoclonal Antibody in KRAS-Mutant Colorectal Cancer Cells by Silica-Coated Magnetic Nanoparticle Conjugation

Background: The therapeutic potential of epidermal growth factor receptor (EGFR) targeting in colorectal cancer (CRC) is hindered by the presence of KRAS codon 12 activating mutations, prevalent in approximately 25% of advanced CRC cases. This study investigates the role of reactive oxygen species (...

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Bibliographic Details
Main Authors: Maedeh Yousefi, Hamed Farzi-Khajeh, Mostafa Akbarzadeh-Khiavi, Azam Safary, Khosro Adibkia
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2024-10-01
Series:Pharmaceutical Sciences
Subjects:
colorectal cancer
egfr
kras mutant
magnetic nanoparticles
pegylation
reactive oxygen species
Online Access:https://ps.tbzmed.ac.ir/PDF/ps-30-444.pdf
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https://ps.tbzmed.ac.ir/PDF/ps-30-444.pdf

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