Complement 3a receptor 1 on macrophages and Kupffer cells is not required for the pathogenesis of metabolic dysfunction-associated steatotic liver disease

Complement 3a receptor 1 on macrophages and Kupffer cells is not required for the pathogenesis of metabolic dysfunction-associated steatotic liver disease

Together with obesity and type 2 diabetes, metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global epidemic. Activation of the complement system and infiltration of macrophages has been linked to progression of metabolic liver disease. The role of complement receptors in...

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Bibliographic Details
Main Authors: Edwin A Homan, Ankit Gilani, Alfonso Rubio-Navarro, Maya A Johnson, Odin M Schaepkens, Eric Cortada, Renan Pereira de Lima, Lisa Stoll, James C Lo
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-01-01
Series:eLife
Subjects:
C3ar1
macrophages
kupffer cells
metabolic dysfunction-associated steatotic liver disease
fatty liver disease
non-alcoholic fatty liver disease
Online Access:https://elifesciences.org/articles/100708
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