Simultaneous and sequential enzymatic cascades for asymmetric synthesis of chiral beta-hydroxyamide derivatives promoted by alcohol dehydrogenases and nitrile hydratases

Asymmetric synthesis of optically pure (S)-3-hydroxy-3-phenylpropanamide derivatives from o-, m- and p-substituted benzoylacetonitrile was achieved by two enzymatic one-pot protocols, the simultaneous and the sequential two-step linear cascade promoted by alcohol dehydrogenase (ADH) and nitrile hydr...

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Bibliographic Details
Main Authors: Everton A. Tordato, Shirley A. Castilho, Humberto M. S. Milagre, Cintia D. F. Milagre
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Green Chemistry Letters and Reviews
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Online Access:https://www.tandfonline.com/doi/10.1080/17518253.2024.2343707
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