Trehalose polyphleates participate in Mycobacterium abscessus fitness and pathogenesis

Trehalose polyphleates participate in Mycobacterium abscessus fitness and pathogenesis

ABSTRACT Mycobacteria produce a large repertoire of surface-exposed lipids with major biological functions. Among these lipids, trehalose polyphleates (TPPs) are instrumental in the infection of Mycobacterium abscessus by the therapeutic phage BPs. However, while the biosynthesis and transport of TP...

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Main Authors: Silke Malmsheimer, Wassim Daher, Yara Tasrini, Claire Hamela, John Jairo Aguilera-Correa, Christian Chalut, Graham F. Hatfull, Laurent Kremer
Format: Article
Language:English
Published: American Society for Microbiology 2024-12-01
Series:mBio
Subjects:
Mycobacterium abscessus
trehalose polyphleates
MmpL10
infection
pathogenesis
macrophage
Online Access:https://journals.asm.org/doi/10.1128/mbio.02970-24
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https://journals.asm.org/doi/10.1128/mbio.02970-24

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