Effect of a single-dose denosumab on mineral homeostasis in infertile men: insights from a pilot intervention study and a randomized controlled trial

Effect of a single-dose denosumab on mineral homeostasis in infertile men: insights from a pilot intervention study and a randomized controlled trial

Abstract Background Denosumab, a drug that inhibits RANKL to reduce bone resorption in osteoporotic postmenopausal women, has been shown to improve semen quality in a subgroup of infertile men. This study aimed to investigate the effects of denosumab on mineral homeostasis in young infertile men. Me...

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Bibliographic Details
Main Authors: Sam Kafai Yahyavi, Rune Holt, Li Juel Mortensen, Ida Marie Boisen, Lív Bech Árting, Anne Jørgensen, Anders Juul, Martin Blomberg Jensen
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Medicine
Subjects:
Denosumab
Calcium
PTH
Vitamin D
Phosphate
Randomized controlled trials
Online Access:https://doi.org/10.1186/s12916-025-03958-7
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https://doi.org/10.1186/s12916-025-03958-7

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