JAK-STAT1 as therapeutic target for EGFR deficiency-associated inflammation and scarring alopecia

JAK-STAT1 as therapeutic target for EGFR deficiency-associated inflammation and scarring alopecia

Abstract The hair follicle stem cell niche is an immune-privileged microenvironment, characterized by reduced antigen presentation, thus shielding against permanent immune-mediated tissue damage. In this study, we demonstrated the protective role of hair follicle-specific epidermal growth factor rec...

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Main Authors: Karoline Strobl, Jörg Klufa, Regina Jin, Lena Artner-Gent, Dana Krauß, Philipp Novoszel, Johanna Strobl, Georg Stary, Igor Vujic, Johannes Griss, Martin Holcmann, Matthias Farlik, Bernhard Homey, Maria Sibilia, Thomas Bauer
Format: Article
Language:English
Published: Springer Nature 2024-11-01
Series:EMBO Molecular Medicine
Subjects:
Cicatricial Alopecia
EGFR
Hair Follicle
Immune Privilege
JAK Inhibitors
Online Access:https://doi.org/10.1038/s44321-024-00166-3
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https://doi.org/10.1038/s44321-024-00166-3

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