Advanced TiO2-polypyrrole nanostructures enhance glucose detection accuracy with cutting-edge non-enzymatic electrochemical capabilities
High level of glucose in the blood lead to a serious disease especially in the heart, blood vessels, eyes, kidney & nerves etc. in human and thus its detection has an important aspect in medical sector and food industry as well. According to World Health organization (WHO), it was speculated...
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Elsevier
2025-06-01
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| Series: | Chemical Physics Impact |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667022425000064 |
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| author | Ashima Thakur Sweety Pal Usha Sharma Ajit Sharma Meenakshi Choudhary Mukesh C. Joshi Herma Dina Setiabudi Prabal Pratap Singh Atheesha Singh Sudheesh K. Shukla |
| author_facet | Ashima Thakur Sweety Pal Usha Sharma Ajit Sharma Meenakshi Choudhary Mukesh C. Joshi Herma Dina Setiabudi Prabal Pratap Singh Atheesha Singh Sudheesh K. Shukla |
| author_sort | Ashima Thakur |
| collection | DOAJ |
| description | High level of glucose in the blood lead to a serious disease especially in the heart, blood vessels, eyes, kidney & nerves etc. in human and thus its detection has an important aspect in medical sector and food industry as well. According to World Health organization (WHO), it was speculated that the number of overall diabetes's patient will increase globally by 2025. Thus, there is a notable need for the glucose sensors that may give quick response, extremely sensitive and economically sound to the regular blood glucose monitoring. In this study we have developed and deigned a cheapest, reliable and high performance TiO2-Polypyrrole (TiO2-PPy) nanocomposite based non-enzymatic electrochemical sensor for glucose detection. This hybrid nanostructured material has shown excellent electro catalytic properties toward glucose oxidation due to its high surface area. The resulting material were characterized by an optical and electrochemical techniques to validate its structural architecture and catalytic activity. Electrochemical studies revealed that the TiO2-PPy nanocomposite based sensor exhibited remarkable stability and sensitivity towards non-enzymatic glucose detection. The developed non-enzymatic glucose detection sensor demonstrated sensitivity of 678.57 μAmM−1cm2 with linear range of 0 mM to 5.5 mM The enhanced performance is attributed to the synergistic effects of both the metallic as well as polymer moieties in the nanocomposite, where polypyrrole provides an outstanding conductive network for an efficient electron transfer, while TiO2 offers an active Centre for oxidation of glucose molecule. Additionally, TiO2-PPy the sensor confirmed the excellent stability and reproducibility, along with strong potential for practical application in real sample analysis. Therefore, the proposed nanocomposite holds great promise for the development of sustainable and environmentally friendly glucose sensing devices. |
| format | Article |
| id | doaj-art-f4b6f7ee8c3c4579b6925fa472d0dc40 |
| institution | Kabale University |
| issn | 2667-0224 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Chemical Physics Impact |
| spelling | doaj-art-f4b6f7ee8c3c4579b6925fa472d0dc402025-01-17T04:52:26ZengElsevierChemical Physics Impact2667-02242025-06-0110100818Advanced TiO2-polypyrrole nanostructures enhance glucose detection accuracy with cutting-edge non-enzymatic electrochemical capabilitiesAshima Thakur0Sweety Pal1Usha Sharma2Ajit Sharma3Meenakshi Choudhary4Mukesh C. Joshi5Herma Dina Setiabudi6Prabal Pratap Singh7Atheesha Singh8Sudheesh K. Shukla9Department of Chemistry, School of Chemical Engineering and Physical Sciences, Lovely Professional University, Phagwara, Punjab 144411, IndiaDepartment of Biomedical Engineering & Life Sciences, Shobhit Institute of Engineering & Technology (Deemed-to-be University), Modipuram 250110, Meerut, U.P., IndiaDepartment of Zoology, School of Engineering and Biosciences, Lovely Professional University, Phagwara, Punjab 144411, IndiaDepartment of Chemistry, School of Chemical Engineering and Physical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India; Centre for Nanoscience and Nano bioelectronics, School of Chemical Engineering and Physical Sciences, Lovely Professional University, Phagwara, Punjab 144411, IndiaDepartment of Chemistry, School of Chemical Engineering and Physical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India; Centre for Nanoscience and Nano bioelectronics, School of Chemical Engineering and Physical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India; Corresponding authors.Department of Chemistry, Kirori Mal College, University of Delhi, Delhi, 110007, IndiaFaculty of Chemical & Process Engineering Technology, Universiti Malaysia Pahang Al-Sultan Abdullah, Lebuh Persiaran Tun Khalil Yaakob, 26300 Gambang, Pahang, MalaysiaDepartment of Chemistry, GLA University, Mathura (UP), 281406, IndiaWater and Health Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, 2028, South AfricaDepartment of Chemistry, School of Chemical Engineering and Physical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India; Centre for Nanoscience and Nano bioelectronics, School of Chemical Engineering and Physical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India; Department of Chemical Sciences, University of Johannesburg, Doornfontein Campus, P.O. Box 17011, Johannesburg, 2028, South Africa; Corresponding authors.High level of glucose in the blood lead to a serious disease especially in the heart, blood vessels, eyes, kidney & nerves etc. in human and thus its detection has an important aspect in medical sector and food industry as well. According to World Health organization (WHO), it was speculated that the number of overall diabetes's patient will increase globally by 2025. Thus, there is a notable need for the glucose sensors that may give quick response, extremely sensitive and economically sound to the regular blood glucose monitoring. In this study we have developed and deigned a cheapest, reliable and high performance TiO2-Polypyrrole (TiO2-PPy) nanocomposite based non-enzymatic electrochemical sensor for glucose detection. This hybrid nanostructured material has shown excellent electro catalytic properties toward glucose oxidation due to its high surface area. The resulting material were characterized by an optical and electrochemical techniques to validate its structural architecture and catalytic activity. Electrochemical studies revealed that the TiO2-PPy nanocomposite based sensor exhibited remarkable stability and sensitivity towards non-enzymatic glucose detection. The developed non-enzymatic glucose detection sensor demonstrated sensitivity of 678.57 μAmM−1cm2 with linear range of 0 mM to 5.5 mM The enhanced performance is attributed to the synergistic effects of both the metallic as well as polymer moieties in the nanocomposite, where polypyrrole provides an outstanding conductive network for an efficient electron transfer, while TiO2 offers an active Centre for oxidation of glucose molecule. Additionally, TiO2-PPy the sensor confirmed the excellent stability and reproducibility, along with strong potential for practical application in real sample analysis. Therefore, the proposed nanocomposite holds great promise for the development of sustainable and environmentally friendly glucose sensing devices.http://www.sciencedirect.com/science/article/pii/S2667022425000064Electrochemical sensorNon-enzymatic glucose detectionGlucose oxidationHybrid nanostructured materialsDiabetes |
| spellingShingle | Ashima Thakur Sweety Pal Usha Sharma Ajit Sharma Meenakshi Choudhary Mukesh C. Joshi Herma Dina Setiabudi Prabal Pratap Singh Atheesha Singh Sudheesh K. Shukla Advanced TiO2-polypyrrole nanostructures enhance glucose detection accuracy with cutting-edge non-enzymatic electrochemical capabilities Chemical Physics Impact Electrochemical sensor Non-enzymatic glucose detection Glucose oxidation Hybrid nanostructured materials Diabetes |
| title | Advanced TiO2-polypyrrole nanostructures enhance glucose detection accuracy with cutting-edge non-enzymatic electrochemical capabilities |
| title_full | Advanced TiO2-polypyrrole nanostructures enhance glucose detection accuracy with cutting-edge non-enzymatic electrochemical capabilities |
| title_fullStr | Advanced TiO2-polypyrrole nanostructures enhance glucose detection accuracy with cutting-edge non-enzymatic electrochemical capabilities |
| title_full_unstemmed | Advanced TiO2-polypyrrole nanostructures enhance glucose detection accuracy with cutting-edge non-enzymatic electrochemical capabilities |
| title_short | Advanced TiO2-polypyrrole nanostructures enhance glucose detection accuracy with cutting-edge non-enzymatic electrochemical capabilities |
| title_sort | advanced tio2 polypyrrole nanostructures enhance glucose detection accuracy with cutting edge non enzymatic electrochemical capabilities |
| topic | Electrochemical sensor Non-enzymatic glucose detection Glucose oxidation Hybrid nanostructured materials Diabetes |
| url | http://www.sciencedirect.com/science/article/pii/S2667022425000064 |
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