Conditional deletion of TRPC1 channel modulates synaptic plasticity, long term depression, and memory extinction in Fragile X syndrome mice

Conditional deletion of TRPC1 channel modulates synaptic plasticity, long term depression, and memory extinction in Fragile X syndrome mice

Summary: Group I metabotropic glutamate receptors (mGluRs), particularly mGluR5, regulate synaptic plasticity via long-term depression (mGluR-LTD), a process implicated in declarative memory. We previously identified TRPC1, a highly expressed hippocampal ion channel, as a key mGluR5 effector. Using...

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Bibliographic Details
Main Authors: Farah Issa, Xavier Yerna, Thibaud Parpaite, Caren Jabbour, Olivier Schakman, Nicolas Tajeddine, Roberta Gualdani, Philippe Gailly
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:iScience
Subjects:
Genetics
Molecular biology
Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422501346X
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