Inhibition of acid or neutral sphingomyelinases differentially impacts RNA and protein cargo sorting to extracellular vesicles

Inhibition of acid or neutral sphingomyelinases differentially impacts RNA and protein cargo sorting to extracellular vesicles

Summary: Extracellular vesicles (EVs) form through regulated biogenesis processes involving sphingomyelinases (SMases), enzymes that metabolize sphingomyelin to produce ceramide—a lipid influencing membrane rigidity and essential for EV generation. This study explores the impact of inhibiting neutra...

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Bibliographic Details
Main Authors: Juan-Carlos A. Padilla, Seda Barutcu, Jonathan Boulais, Janaína Carla da Silva, Yiran Chen, Easin Syed, Eunjeong Kwon, Eric Lécuyer
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:iScience
Subjects:
Biological sciences
Cell biology
Organizational aspects of cell biology
Omics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225007011
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