Post-translational modifications of cancer immune checkpoints: mechanisms and therapeutic strategies

Post-translational modifications of cancer immune checkpoints: mechanisms and therapeutic strategies

Abstract Immunotherapies, particularly immune checkpoint inhibitors (ICIs), have revolutionized cancer clinical management, but low response rates and treatment resistance remain challenging. Protein post-translational modifications (PTMs) are critical for governing protein expression, localization,...

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Main Authors: Haiqing Jia, Lei Jiang, Xiaoyu Shen, Huinan Ye, Xinguang Li, Liwei Zhang, Yanyan Hu, Dandan Song, Hui Jia, Zhe Wang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Molecular Cancer
Subjects:
Immune checkpoints
Post-translational modifications
Immunotherapy
Treatment resistance
Combination treatment
Online Access:https://doi.org/10.1186/s12943-025-02397-5
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https://doi.org/10.1186/s12943-025-02397-5

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