Inhibition of FAM19A5 reverses synaptic loss and cognitive decline in mouse models of Alzheimer’s disease

Inhibition of FAM19A5 reverses synaptic loss and cognitive decline in mouse models of Alzheimer’s disease

Abstract Background FAM19A5 is a secretory protein primarily expressed in neurons. Although its role in synaptic function has been suggested, the precise molecular mechanisms underlying its effects at the synapse remain unclear. Given that synaptic loss is a critical hallmark of Alzheimer’s disease...

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Main Authors: Han-Byul Kim, Sangjin Yoo, Hoyun Kwak, Shi-Xun Ma, Ryunhee Kim, Minhyeok Lee, Nui Ha, Soonil Pyo, Soon-Gu Kwon, Eun-Ho Cho, Sang-Myeong Lee, Juwon Jang, Won Kyum Kim, Hae-Chul Park, Minkyung Baek, Yosub Park, Ji-Young Park, Jin-Woo Park, Sun Wook Hwang, Jong-Ik Hwang, Jae Young Seong
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Alzheimer’s Research & Therapy
Subjects:
FAM19A5
LRRC4B
NS101
Alzheimer’s disease
Mushroom spine
Synapse restoration
Online Access:https://doi.org/10.1186/s13195-025-01813-8
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https://doi.org/10.1186/s13195-025-01813-8

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