Developing an On‐Resin Synthesis of α‐Galactosylceramide‐Peptide Conjugate Vaccines

Developing an On‐Resin Synthesis of α‐Galactosylceramide‐Peptide Conjugate Vaccines

Abstract The covalent attachment of peptide antigens to the NKT cell agonist, α‐galactosylceramide (αGalCer), generates self‐adjuvanting vaccines that prevent and/or eliminate disease in animal models of cancer and infectious disease. To date, the manufacture of these glycolipid‐peptide (GLP) conjug...

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Main Authors: Dr. Michael A. Meijlink, Dr. Susanna T. S. Chan, Kathryn J. Farrand, Sarah L. Draper, Dr. Oliva K. Burn, Jasmine M. Seifert‐Simpson, Ngarangi C. Mason, Dr. Lisa M. Connor, Prof. Ian F. Hermans, Prof. Gavin F. Painter, Dr. Benjamin J. Compton
Format: Article
Language:English
Published: Wiley-VCH 2025-01-01
Series:ChemistryEurope
Subjects:
glycolipid-peptide conjugate
α-galactosylceramide
solid-phase vaccine synthesis
cytotoxic T lymphocytes
Online Access:https://doi.org/10.1002/ceur.202400059
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https://doi.org/10.1002/ceur.202400059

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