Assessing the Theoretical Efficacy of Combination Therapy Against Gram-Negative Infections in Neutropenic Pediatric Cancer Patients: Insights from the Statistical Analysis of Survey Data

Assessing the Theoretical Efficacy of Combination Therapy Against Gram-Negative Infections in Neutropenic Pediatric Cancer Patients: Insights from the Statistical Analysis of Survey Data

<b>Background</b>: Empirical antibacterial therapy for febrile neutropenia reduces mortality due to Gram-negative blood stream infections (BSIs). Pediatric guidelines recommend monotherapy with an antipseudomonal beta-lactam or a carbapenem and to add a second anti-Gram-negative agent in...

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Main Authors: Elio Castagnola, Francesca Bagnasco, Alessio Mesini, Philipp K. A. Agyeman, Roland A. Ammann, Marta Arrabito, Fabianne Carlesse, Maria Rosaria D’Amico, Giovanna Giagnuolo, Gabrielle M. Haeusler, Evgeny A. Idelevich, Christa Koenig, Thomas Lehrnbecher, Marie Luckowitsch, Mariaclaudia Meli, Giuseppe Menna, Giovanna Russo, Maria Elena Santolaya de Pablo, Arne Simon, Galina Solopova, Lillian Sung, Annalisa Tondo, Andreas H. Groll
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Antibiotics
Subjects:
febrile neutropenia
empiric antibiotic therapy
combination therapy
Gram-negative bacteriamia
Online Access:https://www.mdpi.com/2079-6382/13/12/1160
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