Reduction of Dietary Fat Rescues High-Fat Diet-Induced Depressive Phenotypes and the Associated Hippocampal Astrocytic Deficits in Mice

Reduction of Dietary Fat Rescues High-Fat Diet-Induced Depressive Phenotypes and the Associated Hippocampal Astrocytic Deficits in Mice

Background/Objectives: Depression is frequently comorbid with obesity. We previously showed that astrocyte-mediated hyperactive ventral hippocampal glutamatergic afferents to the nucleus accumbens determined the exhibition of depression-like behaviors in obese murine models. However, it remains uncl...

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Bibliographic Details
Main Authors: Kai-Pi Cheng, Hsin-Hao Chao, Chin-Ju Hsu, Sheng-Feng Tsai, Yen-Ju Chiu, Yu-Min Kuo, Yun-Wen Chen
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Metabolites
Subjects:
astrocyte
obesity
depression
GLAST
GLT-1
Online Access:https://www.mdpi.com/2218-1989/15/7/485
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