Emergence of an XDR Klebsiella pneumoniae ST5491 strain co-harboring NDM-5, MCR-1.1, tmexCD1-toprJ1, and a novel plasmid carrying CTX-M-15

Emergence of an XDR Klebsiella pneumoniae ST5491 strain co-harboring NDM-5, MCR-1.1, tmexCD1-toprJ1, and a novel plasmid carrying CTX-M-15

ObjectiveThe rapid emergence of antimicrobial resistance (AMR) in Klebsiella pneumoniae poses a significant global health threat. The study aimed to analyze and describe the genomic architecture and resistance mechanisms of an extensively drug-resistant (XDR) K. pneumoniae isolate, KP09, by focusing...

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Bibliographic Details
Main Authors: Yinfei Fang, Xiangchen Li, Zhaoxia Wu, Yongjin Fang, Yeping Wang, Xiaobing Li, Lihong Bu, Keqiang Chen, Kai Shen, Yongjun Ma, Mingjuan Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Microbiology
Subjects:
Klebsiella pneumoniae
extensively drug-resistant (XDR)
genomic analysis
antimicrobial resistance (AMR)
IncFIA/IncFII/IncQ1 hybrid plasmid
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1581851/full
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