Melatonin supplementation attenuates cuproptosis and ferroptosis in aging cumulus and granulosa cells: potential for improving IVF outcomes in advanced maternal age

Melatonin supplementation attenuates cuproptosis and ferroptosis in aging cumulus and granulosa cells: potential for improving IVF outcomes in advanced maternal age

Abstract Background Advanced maternal age is associated with decreased oocyte quantity and quality and in vitro fertilization (IVF) success rates. This study aimed to investigate whether melatonin supplementation can improve IVF outcomes in women of advanced maternal age by modulating cuproptosis an...

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Bibliographic Details
Main Authors: Kuan-Hao Tsui, Chia-Jung Li, Li-Te Lin
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Reproductive Biology and Endocrinology
Subjects:
Antioxidant therapy
Reproductive aging
Oocyte quality
Oxidative stress
Assisted reproduction
Mitochondrial function
Online Access:https://doi.org/10.1186/s12958-024-01311-w
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https://doi.org/10.1186/s12958-024-01311-w

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