IMPAIRMENT OF HERP E3 LIGASE ACTIVITY BY MUTANT POLYGLUTAMINE PROTEINS: A NOVEL MECHANISM IN POLYGLUTAMINE DISEASE NEUROPATHOLOGY
Herp (Homocysteine-induced endoplasmic reticulum protein) is an endoplasmic reticulum stress (ERS) response protein that regulates the clearance of misfolded proteins via the ER-associated degradation (ERAD) pathway. This study demonstrates for the first time that Herp possesses E3 ubiquitin ligase...
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| Format: | Article |
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| Language: | English |
| Published: |
PAGEPress Publications
2025-08-01
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| Series: | European Journal of Histochemistry |
| Subjects: | |
| Online Access: | https://www.ejh.it/ejh/article/view/4316 |
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