Genetically engineered MSC-derived hybrid cellular vesicles for ROS-scavenging and mitochondrial homeostasis in hepatic ischemia-reperfusion injury

Genetically engineered MSC-derived hybrid cellular vesicles for ROS-scavenging and mitochondrial homeostasis in hepatic ischemia-reperfusion injury

Hepatic ischemia-reperfusion injury (IRI) poses a significant clinical challenge in liver surgery and transplantation, primarily mediated through oxidative stress, mitochondrial dysfunction, and inflammatory activation. Herein, we developed SOD2-Res@CVs, an engineered vesicular platform combining SO...

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Bibliographic Details
Main Authors: Pu Shen, Kaijun Huang, Xuanlin Zhang, Guiyuan Yin, Meiting Qin, Hua Ma, Zhijin Fan, Yuhui Liao
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Materials Today Bio
Subjects:
Hepatic ischemia-reperfusion injury
Cellular vesicles
Mesenchymal stem cell
Mitochondrial homeostasis
Resveratrol
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425007859
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